What criteria does deCODEme use for selecting disease SNPs?
It is imperative to note that deCODEme only reports risk based on well validated genetic variants (SNPs). Not only does deCODEme require that the association between genetic variant and a disease is truly statistically significant, it also requires that the association has been replicated in at least two independent studies. To include risk estimates based on unverified variants, that have only marginal evidence behind them, is unjustified and scientifically unsound. The lists of relevant genetic variants will be constantly updated as more candidates meet the criterion. The published reference from which a relative risk estimate is calculated is provided. It is however important to note that a user might not find the exact relative risk number displayed in deCODEme in the corresponding reference. This is because, in most scientific publications, the relative risks, or odds-ratios, estimated are usually between two alleles or two genotypes. Since the average population risk can be expre
