Why does deCODEme in some cases exclude known disease SNPs?
In some cases, variants with a verified disease association are excluded from the genetic risk estimates in deCODEme service. This is done when multiple variants from the same chromosomal region are strongly correlated and therefore redundant. In such instances deCODEme choose the minimum number of genetic variants that capture all the risk conferred by the full set of SNPs. In this case no information about genetic risk is lost from excluding some variants in the risk prediction. See Selection of risk associated genetic variants for more information.
